Conolidine’s analgesic outcomes stem from its conversation with non-opioid pain pathways. As opposed to opioids, which bind to µ-opioid receptors in the central anxious process, conolidine modulates alternate molecular targets. A Science Advances research located that conolidine interacts Using the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://whatischronicpain02119.thezenweb.com/the-ultimate-guide-to-alternative-natural-pain-relief-to-replace-traditional-painkillers-77215259