BACKGROUND:Tissue inhibitor of metalloproteinases-1 (TIMP-1) displays pleiotropic activities. both dependent and independent of its inhibitory activity on matrix metalloproteinases (MMPs). In the central nervous system (CNS). TIMP-1 is strongly upregulated in reactive astrocytes and cortical neurons following excitotoxic/inflammatory stimuli. https://www.getpureroutine.com/hot-offer-rosy-teacups-dogwood-discount-best-super/